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In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted
M Takahashi1, B Fritz-Zieroth, T Chikugo
1Research Department, Nihon Schering, Japan.
Acta Neurochirurgica. Supplementum
|January 1, 1994
Abstract:
Apparent diffusion coefficients (ADCs) of tissue water were determined in chronic brain lesions of a rat stroke model, the stroke-prone spontaneously hypertensive rat, and compared with histology. ADCs increased in the order normal < edema < gliosis < cyst. The differences between individual groups were statistically significant. The increase in ADC is thought to mainly reflect a relative increase in the extracellular space in brain tissue. ADC may be a new parameter for tissue characterization.