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[Bullous pemphigoid and multiple sclerosis]

A Tohme1, L Mattar, A Zebouni

  • 1Service de Médecine Interne de l'Hôtel-Dieu de France, Beyrouth, Liban.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
Summary
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Bullous pemphigoid (BP) is rarely seen in multiple sclerosis (MS) patients. This case report details a successful steroid treatment for BP in an MS patient, with no recurrence observed.

Area of Science:

  • Immunodermatology
  • Neuroimmunology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Bullous pemphigoid (BP) is an autoimmune blistering disease typically affecting the elderly.
  • The co-occurrence of MS and BP is rare, with unclear underlying mechanisms.

Observation:

  • A 40-year-old female patient with a 15-year history of multiple sclerosis presented with bullous pemphigoid.
  • The diagnosis of bullous pemphigoid was confirmed through histological and immunological examinations.
  • The patient had no prior history of blistering diseases.

Findings:

  • The patient's bullous pemphigoid was successfully treated with systemic steroids.
  • No recurrence of bullous pemphigoid was noted during a six-month follow-up period.

Related Experiment Videos

  • This case adds to the limited literature on the association between MS and BP.

    • Implications:

    • The findings suggest that immunosuppressive therapies used for MS might not prevent BP, or that shared immune dysregulation could play a role.
    • Further research is warranted to elucidate the potential immunological links between multiple sclerosis and bullous pemphigoid.
    • This case highlights the importance of considering BP in MS patients presenting with cutaneous blistering.