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8-Amino-2'-deoxyadenosine: 2'-deoxythymidine base pairing: identification of novel reverse Hoogsteen mode in solution
R K Kumar1, A D Gunjal, K N Ganesh
1Organic Chemistry Division, National Chemical Laboratory, Pune, India.
Biochemical and Biophysical Research Communications
|October 28, 1994
Abstract:
A novel reversed Hoogsteen mode is observed for the base-pairing of 8-amino-2'-deoxyadenosine with 2'-deoxythymidine in low dielectric solvent. The results may have important significance for designing novel DNA duplexes and triplexes incorporating 8-amino-dA.