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Glutamate inhibits ingestive behaviour
I Bednar1, M Qian, G A Qureshi
1Department of Clinical Neuroscience, Karolinska Institute, Huddinge, Sweden.
Journal of Neuroendocrinology
|August 1, 1994
Summary
Reserpine-induced immobility in rats was overcome by MK801, a glutamate receptor antagonist, which restored feeding behavior. This suggests glutamate plays a key role in regulating ingestive responses, potentially interacting with dopamine.
Area of Science:
- Neuroscience
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Reserpine treatment induces immobility and suppresses feeding behavior in rats.
- Dopamine agonist apomorphine stimulates locomotion but not feeding in reserpinized rats.
Purpose of the Study:
- To investigate the role of glutamate in regulating ingestive behavior.
- To explore the interaction between glutamate and dopamine in feeding control.
Main Methods:
- Utilized Grill's intraoral intake test to measure sucrose ingestion in rats.
- Administered reserpine, apomorphine, and the N-methyl-D-aspartate receptor antagonist MK801.
- Measured glutamate and dopamine levels in the nucleus of the solitary tract.
Main Results:
- MK801 stimulated both locomotion and ingestion in reserpinized rats.
- MK801 facilitated sucrose ingestion and antagonized cholecystokinin octapeptide inhibition in untreated rats.
- Cholecystokinin octapeptide and sucrose ingestion increased glutamate in the nucleus of the solitary tract; MK801 blocked these increases.
Conclusions:
- Glutamate is involved in suppressing ingestive responses induced by reserpine.
- Dopamine and glutamate may interact within the nucleus of the solitary tract to control feeding behavior.