[Esophageal lesions induced by iron tablets]
1Patologisk anatomisk avdeling Ullevål sykehus, Oslo.
Summary
Iron sulphate tablets, particularly sustained-release formulations, can cause esophageal ulcers in elderly, bedridden patients. Clinicians should carefully weigh the benefits against the risks of iron supplementation in this vulnerable population.
Area of Science:
- Gastroenterology
- Histopathology
- Clinical Medicine
Context:
- Esophageal injury is a serious complication that can arise from medication use.
- Iron supplementation is common, especially in elderly and bedridden individuals.
- Sustained-release iron sulphate tablets have been implicated in gastrointestinal issues.
Purpose:
- To investigate the link between iron sulphate tablets and esophageal ulcers.
- To highlight the underdiagnosis of medication-induced esophageal injury.
- To alert clinicians to potential risks associated with iron supplementation in specific patient groups.
Summary:
- Histological examination revealed esophageal ulcers with iron salt deposition in 12 patients over three years.
- Iron sulphate tablets, particularly sustained-release types, were identified as the likely cause in 10 out of 12 patients.
- One patient experienced esophageal perforation, leading to death, underscoring the severity of this complication.
Impact:
- This study suggests that iron sulphate tablets may be an underrecognized cause of esophageal injury.
- It emphasizes the need for careful consideration of iron supplementation risks in elderly and bedridden patients.
- Clinical awareness and diagnostic vigilance are crucial to prevent severe outcomes from medication-induced esophageal damage.
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