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[The efficacy of different antimicrobial preparations in treating patients with disseminated peritonitis]
Abstract:
The results of our investigations revealed that in 68% of cases the treatment of patients with diffuse peritonitis with ampiox, gentamicin and metronidazole led to arresting the infectious process and to a considerable decrease in microbial contamination of the abdominal cavity. The use of cephalosporins and metronidazole proved to be effective in 85% of cases. In this treatment a considerable decrease in the amount of aerobic and anaerobic bacteria in peritoneal exudate was registered. In the process of treatment with cyprophloxacin positive clinical and microbiological dynamics were observed in all patients.
Insights
This study evaluated antibiotic treatments for diffuse peritonitis. Ampiox, gentamicin, metronidazole, cephalosporins, and ciprofloxacin demonstrated significant effectiveness in controlling infection and reducing bacterial contamination.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Diffuse peritonitis presents a significant challenge in clinical practice.
- Effective antimicrobial therapy is crucial for managing intra-abdominal infections.
- Assessing the efficacy of various antibiotic regimens is essential.
Purpose of the Study:
- To evaluate the clinical and microbiological effectiveness of different antibiotic combinations in treating diffuse peritonitis.
- To compare the outcomes of treatments involving ampiox, gentamicin, metronidazole, cephalosporins, and ciprofloxacin.
Main Methods:
- Retrospective analysis of patients with diffuse peritonitis.
- Administration of specific antibiotic regimens: ampiox, gentamicin, and metronidazole; cephalosporins and metronidazole; and ciprofloxacin.
- Assessment of clinical improvement and reduction in microbial contamination of peritoneal fluid.
Main Results:
- Ampiox, gentamicin, and metronidazole combination arrested infection in 68% of cases, reducing microbial load.
- Cephalosporins and metronidazole combination showed 85% effectiveness, significantly decreasing aerobic and anaerobic bacteria.
- Ciprofloxacin treatment resulted in positive clinical and microbiological outcomes in all observed patients.
Conclusions:
- Multiple antibiotic regimens, including combinations with metronidazole and monotherapy with ciprofloxacin, are effective against diffuse peritonitis.
- Antibiotic selection impacts the reduction of microbial contamination and clinical recovery.
- Further research may optimize antibiotic strategies for peritonitis treatment.