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Urinary system

C F Lynch1, M B Cohen

  • 1Department of Preventive Medicine and Environment Health, University of Iowa, Iowa City 52242.

Cancer
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

This study analyzed 76,303 urinary tract cancers, finding transitional cell carcinoma and adenocarcinoma are most common. Histologic type significantly impacts cancer incidence and survival rates by site.

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Area of Science:

  • Urologic oncology
  • Cancer epidemiology
  • Histopathology

Background:

  • National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program data is vital for cancer statistics.
  • Previous SEER reports lacked detailed histologic type breakdowns for specific cancer sites.
  • This study addresses this gap by analyzing urinary tract cancers by histologic type.

Purpose of the Study:

  • To present detailed data on urinary tract cancers categorized by histologic type.
  • To analyze incidence and survival trends based on specific histologic subtypes within urinary tract cancer sites.

Main Methods:

  • Utilized SEER program data for 76,303 histologically confirmed urinary tract cancers (in situ or invasive) diagnosed between 1973-1987.
  • Categorized urinary tract cancers into kidney and renal pelvis, ureter, urinary bladder, urethra, and other urinary sites.

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  • Evaluated histologic types in relation to site, age, sex, race, incidence, and survival.

    • Main Results:

    • Transitional cell carcinomas (72.0%) and adenocarcinomas (22.0%) were the predominant histologic types.
    • Adenocarcinoma was most common in the kidney/renal pelvis (renal cell carcinoma), while transitional cell carcinoma dominated other urinary tract sites.
    • Age-adjusted incidence rates for common histologic types were consistently higher in males than females.

    Conclusions:

    • Histologic types like adenocarcinoma (kidney/renal pelvis) and transitional cell carcinoma (urinary bladder) are key drivers of site-specific incidence and survival trends.
    • Future cancer research should prioritize detailed analysis of histologic types within specific cancer sites.
    • This approach will enhance understanding of risk factors and improve clarity on cancer incidence and survival patterns.