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Published on: November 21, 2016
Glycolysis abnormalities in fibromyalgia
J Eisinger1, A Plantamura, T Ayavou
1Department of Rheumatic Diseases--Centre Hospitalier, Toulon, France.
Journal of the American College of Nutrition
|April 1, 1994
Summary
Fibromyalgia (FM) is linked to impaired carbohydrate metabolism, showing higher pyruvate and lower lactate levels. These biochemical abnormalities suggest a need for targeted metabolic therapies in FM patients.
Area of Science:
- Biochemistry
- Metabolic Medicine
- Pain Management
Background:
- Primary fibromyalgia (FM) is a chronic pain condition.
- Current treatments include analgesics and antidepressants.
- FM has been associated with hyperpyruvicemia and reduced muscle high-energy phosphate.
Purpose of the Study:
- To investigate potential carbohydrate metabolism impairments in FM patients.
- To determine if FM is associated with biochemical abnormalities.
Main Methods:
- Studied glycolysis in 25 FM patients, 10 hypothyroidism patients, 15 chronic pain patients, and 36 controls.
- Performed laboratory tests on blood, erythrocytes, and plasma, including pyruvate, lactate, adenosine triphosphate, and enzyme activity.
Main Results:
- Fibromyalgia and hypothyroidism patients showed increased pyruvate and decreased lactate production.
- Adenosine triphosphate and lactate dehydrogenase isoenzymes were decreased specifically in FM patients.
- Glycolysis was not significantly impaired in patients with osteoarticular chronic pain.
Conclusions:
- Findings support that fibromyalgia is associated with biochemical abnormalities.
- These abnormalities suggest a link to carbohydrate metabolism impairment.
- Appropriate metabolic therapy may be required for fibromyalgia management.
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