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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis: an investigational process
Summary
Investigating endophthalmitis after cataract surgery, this study highlights the significant risk posed by bacteria from the patient's own skin flora. Understanding this source is crucial for preventing post-operative infections.
Area of Science:
- Ophthalmology
- Surgical Infections
- Microbiology
Background:
- Endophthalmitis is a serious intraocular infection that can lead to vision loss.
- Cataract surgery is a common procedure with a low but significant risk of endophthalmitis.
- The patient's endogenous microflora, particularly skin flora, is increasingly recognized as a potential source of post-operative ocular infections.
Purpose of the Study:
- To investigate the role of the operating room environment and patient's skin flora in the development of endophthalmitis following cataract surgery.
- To identify the primary microbial sources contributing to post-operative endophthalmitis.
Main Methods:
- Review of clinical cases of endophthalmitis occurring after cataract surgery.
- Analysis of microbial cultures from ocular samples and relevant environmental/skin sites.
- Correlation of identified pathogens with pre-operative and intra-operative factors.
Main Results:
- Patient's own skin flora was identified as a significant source of causative organisms in post-cataract surgery endophthalmitis.
- Specific bacterial species commonly found on skin were frequently isolated from infected eyes.
Conclusions:
- Pre-operative skin preparation and intra-operative aseptic techniques are critical to minimize the risk of endophthalmitis.
- Targeting patient's skin flora is essential in strategies to prevent endophthalmitis after cataract surgery.
