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Antibiotic induced meningitis

Y River1, L Averbuch-Heller, M Weinberger

  • 1Department of Neurology, Hadassah University Hospital, Hebrew University, Jerusalem, Israel.

Journal of Neurology, Neurosurgery, and Psychiatry
|June 1, 1994
PubMed
Summary
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This study details antibiotic-induced meningitis, a rare condition. Penicillin and trimethoprim-sulfamethoxazole can cause meningitis with symptoms like myalgia and confusion, making CSF analysis unreliable for diagnosis.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic-induced meningitis is a rare but significant adverse drug reaction.
  • Previous literature on this condition is limited, particularly regarding specific antibiotics.

Observation:

  • Reported are three patients experiencing antibiotic-induced meningitis.
  • One patient had recurrent meningitis following penicillin administration.
  • Two patients experienced meningitis after trimethoprim-sulfamethoxazole (co-trimoxazole).

Findings:

  • Common symptoms included myalgia, confusion, and low cerebrospinal fluid (CSF) glucose.
  • Penicillin-induced meningitis was documented for the first time.
  • CSF analysis was unreliable in differentiating from partially treated bacterial meningitis.

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Implications:

  • Highlights the potential for antibiotics to cause meningitis.
  • Suggests clinicians should consider drug-induced meningitis in differential diagnosis.
  • Emphasizes the need for careful patient monitoring during antibiotic therapy.