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Cerebral MR in ophthalmoplegia plus
AJNR. American Journal of Neuroradiology
|April 1, 1994
Summary
Magnetic Resonance (MR) imaging reveals brain atrophy and white matter/basal ganglia hyperintensities in ophthalmoplegia plus. These MR patterns are distinct from other mitochondrial disorders, aiding clinical differentiation.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Ophthalmoplegia plus is a rare neurological disorder.
- Understanding its neuroimaging characteristics is crucial for diagnosis.
Purpose of the Study:
- To evaluate Magnetic Resonance (MR) patterns in patients with ophthalmoplegia plus.
- To correlate these MR findings with clinical symptoms.
Main Methods:
- Retrospective analysis of 19 patients with ophthalmoplegia plus.
- MR imaging performed on a 1.5-T scanner using T2-weighted gradient-echo and spin-echo sequences.
Main Results:
- Two main cerebral MR abnormalities identified: brain atrophy and supratentorial white matter/basal ganglia hyperintensities.
- Hyperintensities appeared as focal or diffuse high signal intensity areas.
- Findings were distinct from infarction-like lesions seen in other mitochondrial disorders.
Conclusions:
- MR imaging is sensitive in detecting central nervous system involvement in ophthalmoplegia plus.
- MR findings in ophthalmoplegia plus are nonspecific but differ from other mitochondrial encephalomyopathies.
- Cerebral MR patterns support the clinical differentiation of mitochondrial encephalomyopathies.