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Artificial life extension. The epigenetic approach
P E Kloeden1, R Rössler, O E Rössler
1Department of Mathematics and Computer Science, Deakin University, Geelong, Victoria, Australia.
Annals of the New York Academy of Sciences
|May 31, 1994
Summary
Melatonin, a hormone produced by the pineal gland, may control aging. Studies show it increased lifespan and postponed senescence in mammals, suggesting potential anti-aging effects in humans.
Area of Science:
- Gerontology
- Endocrinology
- Epigenetics
Background:
- Aging is primarily considered a result of genetic programming.
- Epigenetic approaches to aging require understanding underlying genetic factors.
- Recent advances offer new insights into aging control mechanisms.
Purpose of the Study:
- To explore the role of melatonin as a potential aging-controlling hormone.
- To investigate the empirical and theoretical evidence supporting melatonin's effect on aging.
- To propose further research for validating melatonin's anti-aging properties.
Main Methods:
- Empirical studies involving melatonin administration and pineal tissue engraftment in mammals.
- Theoretical evolutionary approach to aging and survivability.
- Analysis of existing data on melatonin use in human volunteers.
Main Results:
- Melatonin administration increased lifespan by 25% and postponed senescence in mice.
- Engraftment of young pineal tissue also extended lifespan and delayed aging.
- Epithalamin, a pineal extract stimulating melatonin, showed beneficial effects in humans.
Conclusions:
- Melatonin emerges as a significant aging-controlling hormone in mammals.
- Evolutionary theory independently supports the existence of a central aging clock, potentially linked to melatonin.
- Further research, including human trials and in vitro studies, is needed to confirm melatonin's anti-aging effects and mechanisms.