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Updated: Aug 10, 2026

Enzyme-linked Immunospot Assay (ELISPOT): Quantification of Th-1 Cellular Immune Responses Against Microbial Antigens
06:13

Enzyme-linked Immunospot Assay (ELISPOT): Quantification of Th-1 Cellular Immune Responses Against Microbial Antigens

Published on: November 23, 2010

[The immune system indices of patients with pseudotuberculosis and concomitant chronic opisthorchiasis]

K I Chuĭkova, N V Vasil'ev

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1994
    PubMed

    The quantitative characteristics of T and B-lymphocytes and their subpopulations (theophylline-resistant and theophylline-sensitive lymphocytes), the reaction of lymphocyte blast transformation (RLBT) after stimulation with phytohemagglutinin (PHA) and the level of circulating immune complexes (CIC) in pseudotuberculosis patients with and without concomitant opisthorchiasis were studied and compared. For control opisthorchiasis patients undergoing dehelminthization and healthy persons were examined. The following results were obtained: in most pseudotuberculosis patients Opisthorchis invasion contributed to the formation of stable and prolonged T lymphopenia, an increase in the content of theophylline-sensitive lymphocytes and CIC, hyporeactivity of T lymphocytes in RLBT. Immunodeficiency developing in chronic opisthorchiasis is reversible, i.e. successful dehelminthization leads to the normalization of immunological characteristics.

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