[Changes in the functional activity of human neutrophils under the action of recombinant interleukin-2]

The effect of recombinant interleukin 2 (rIL-2) on the functional activity of human polymorphonuclear cells (neutrophils) was studied. The study revealed that the preliminary incubation of neutrophils with rIL-2 at a concentration of 10 I.U./ml for 30 minutes significantly enhanced the chemotaxis of neutrophils. In the presence of rIL-2 the tendency towards an increase (p > 0.05) in the spontaneous migration of neutrophils and in the intensity of their respiratory burst was observed. When used at concentrations of 100-1000 I.U./ml, rIL-2 inhibited the phagocytosis of Staphylococcus aureus, and at concentrations of 10 I.U./ml and greater it inhibited the bactericidal activity of neutrophils. The conclusion on the direct action of rIL-2 on the functional activity of human neutrophils was made.