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[Elastin: preparation, characterization, structure, biosynthesis and catabolism]

M P Jacob1

  • 1Laboratoire de Biochimie du Tissu Conjonctif, UA CNRS 1460, Faculté de Médecine, Créteil.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1993
PubMed
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Elastin, a key protein in elastic fibers found in the aorta, lung, and skin, provides essential elasticity. Its development (elastogenesis) is rapid in early life and declines with maturity.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Developmental Biology

Context:

  • Elastin is a crucial structural protein forming elastic fibers in connective tissues.
  • It is abundant in tissues requiring elasticity, such as the aorta, lungs, and skin.
  • Elastin's unique properties stem from its amino acid composition and cross-linking.

Purpose:

  • To summarize the fundamental characteristics of elastin.
  • To outline the developmental process of elastogenesis.
  • To highlight recent research on elastin gene expression and its receptors.

Summary:

  • Elastin is a hydrophobic protein central to elastic fibers, imparting elasticity to tissues like the aorta, lung, and skin.
  • It features unique cross-links, desmosine and isodesmosine.

Related Experiment Videos

  • Elastogenesis, the process of elastin formation, occurs rapidly during fetal and neonatal development, diminishing significantly by adulthood.
  • Research has advanced in understanding the elastin gene, its expression regulation, and a specific receptor for elastin peptides.

    • Impact:

    • Provides a foundational understanding of elastin's structure and function.
    • Informs research on age-related tissue changes and diseases affecting elastic fibers.
    • Highlights the importance of elastin in maintaining tissue integrity and physiological function.