Related Experiment Video
Updated: Aug 4, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
[Chromosomal damages in human lymphocytes induced by low doses of irradiation]
Abstract:
The observation of chromosomal aberrations in circulating lymphocytes is the most sensitive biological indicator of human exposure to ionising radiation. Data at low doses from in vivo and in vitro irradiated lymphocytes are reviewed. Statistical uncertainties mean that no resolution can be made between a linear or threshold response in the range 0-20 mGy of low LET radiation. Above 20 mGy the data conform to the linear quadratic model. The possibility of measuring chromosomal aberrations for dose estimation, to be used in conjunction with epidemiological studies on groups of persons exposed to radiation from the Chernobyl accident, is discussed.
More Related Videos
10:14Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice
Published on: January 11, 2017
08:18Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Published on: September 5, 2017
Related Concept Videos
Nucleotide Excision Repair
Overview of DNA Repair
Chemically...
Fixing Double-strand Breaks
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Spontaneous and Induced Mutations