[Relation between neurogenesis and electrical responses of olfactory receptors]

Structural and functional changes in olfactory epithelium of laboratory mice were studied following the treatment of nasal cavity with zinc sulphate. Different concentrations of zinc sulphate caused olfactory epithelium cells destruction, moreover the degree of this destruction depended on concentration. Direct dependence between morphological regeneration and the EOG amplitude increase was observed after the treatment with 1% zinc sulphate. The epithelium regeneration after the treatment with higher concentration (3 and 5%) was slower and the EOG amplitude fell behind the increase of the olfactory epithelium thickness. The application of different olfactory stimuli allowed to establish that the rate of reactions re-establishment differed with the odorous.