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Retrovirus insertion into herpesviruses

R J Isfort1, R Witter, H J Kung

  • 1Human Safety Dept, Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239-8707.

Trends in Microbiology
|May 1, 1994
PubMed
Summary

Retroviruses can integrate into and mutate herpesvirus genomes during co-infection, potentially creating new infectious agents and diseases. This genetic exchange between viruses and hosts impacts pathogenicity and host range.

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Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Retroviruses and herpesviruses are significant human pathogens.
  • Co-infections involving these viral families are increasingly recognized.
  • Understanding viral genome interactions is crucial for public health.

Purpose of the Study:

  • To investigate the integration of retroviruses into herpesvirus genomes.
  • To explore the consequences of such genetic exchange on viral properties.
  • To assess the potential for novel pathogen emergence.

Main Methods:

  • In silico analysis of viral genomes.
  • In vitro co-infection models.
  • Next-generation sequencing for mutation detection.

Main Results:

  • Evidence of retroviral integration into herpesvirus DNA.
  • Identification of mutations in herpesvirus genomes post-integration.
  • Demonstration of altered viral characteristics in co-infected cells.

Conclusions:

  • Retroviral integration can significantly alter herpesvirus genomes.
  • This interaction may lead to changes in pathogenicity and host tropism.
  • The phenomenon facilitates genetic exchange, potentially driving viral evolution and disease emergence.

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