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Increased disaccharidase activity in human diabetics
The American Journal of Clinical Nutrition
|June 1, 1975
Summary
Increased disaccharidase activity in diabetes may normalize with insulin or glibenclamide treatment. Diet-controlled diabetics showed no change, suggesting medication impacts enzyme levels. This research explores diabetes and enzyme activity.
Area of Science:
- Biochemistry
- Endocrinology
- Gastroenterology
Background:
- Disaccharidase activity is elevated in individuals with diabetes mellitus.
- Understanding the factors influencing disaccharidase levels is crucial for managing diabetic complications.
Purpose of the Study:
- To investigate the effect of different diabetes management strategies on disaccharidase activity.
- To explore potential mechanisms behind altered disaccharidase levels in diabetes.
Main Methods:
- Analysis of disaccharidase activity in diabetic patients.
- Comparison of enzyme levels between diet-controlled diabetics and those on medication (insulin or glibenclamide).
Main Results:
- Diet therapy alone did not alter disaccharidase activity in diabetics.
- Insulin or glibenclamide treatment led to a decrease in disaccharidase activity, moving values toward normal ranges.
- Two diabetic patients on insulin or glibenclamide showed reduced disaccharidase activity.
Conclusions:
- Medications like insulin and glibenclamide may modulate disaccharidase activity in diabetic patients.
- The findings suggest a potential link between glycemic control and intestinal enzyme function.
- Further research is warranted to elucidate the precise mechanisms involved.