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[Bioenergetic radiographic absorptiometry in hemodialysis]
J Ocharan-Corcuera1, A Martínez-Alvarez, J A López-Ruiz
1Hospital de Galdakao, Vizcaya.
Anales De Medicina Interna (Madrid, Spain : 1984)
|May 1, 1994
Summary
Bioenergetic radiographic absorptiometry (BRA) effectively measures bone density in hemodialysis patients with uremic renal osteodystrophy (URO). This non-invasive method correlates bone mineral density with key biochemical markers, aiding in patient management.
Area of Science:
- Nephrology
- Radiology
- Bone Metabolism
Background:
- Uremic renal osteodystrophy (URO) is a common complication in patients undergoing hemodialysis (HD).
- Accurate assessment of bone loss is crucial for managing URO and preventing fractures.
- Existing methods for bone density measurement may involve significant radiation exposure.
Purpose of the Study:
- To evaluate the utility of bioenergetic radiographic absorptiometry (BRA) for assessing total and regional bone mineral density (TMBD and RMBD) in HD patients with URO.
- To determine the correlation between bone mineral density measurements and biochemical markers of bone turnover (alkaline phosphatase, parathyroid hormone).
Main Methods:
- Thirty-one patients on hemodialysis for URO were assessed using BRA.
- Measurements included total body bone mineral density (TMBD) and regional bone mineral density (RMBD) of various skeletal sites.
- Correlations were analyzed between bone density parameters and serum levels of alkaline phosphatase and parathyroid hormone.
Main Results:
- TMBD showed inverse correlations with alkaline phosphatase and parathyroid hormone levels.
- TMBD was inversely correlated with age in female patients.
- HD patients exhibited significantly lower TMBD values compared to chronic renal failure patients and controls.
- All RMBD parameters correlated inversely with alkaline phosphatase levels.
Conclusions:
- BRA is a non-invasive technique with low radiologic exposure for quantifying TMBD and RMBD in URO.
- BRA adequately correlates bone density with alkaline phosphatase and parathyroid hormone levels.
- TMBD accurately assesses total cortical bone, while RMBD facilitates selective analysis of regional bone changes and monitoring disease progression.