[Cytogenetic and genetic changes in myeloid leukemias and myelodysplastic syndrome]

Acute and chronic myeloid leukemias and myelodysplastic syndromes are similarly with other neoplastic disorders characterized by the acquired genetic rearrangements of the leukemic cells. The detection of these rearrangements with cytogenetic and molecular biology methods is of a considerable importance in the management of patients with these disorders. This applies both to the diagnosis, estimation of prognosis and the monitoring of the results of the therapy.