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[The etiological role of enterococci in chronic obstructive bronchitis]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|May 1, 1993
Summary
Enterococcus faecalis bacteria are identified as a primary cause of chronic obstructive bronchitis and a likely contributor to hospital-acquired infections. These drug-resistant enterococci also correlate with reduced immune function and autoimmune responses in patients.
Area of Science:
- Microbiology
- Pulmonology
- Infectious Diseases
Background:
- Chronic obstructive bronchitis (COB) is a significant respiratory illness with complex etiology.
- The role of bacterial pathogens, particularly enterococci, in COB development requires further elucidation.
Purpose of the Study:
- To determine the etiological role of enterococci in the development of chronic obstructive bronchitis.
- To investigate the pathogenic characteristics and antibiotic resistance of enterococci implicated in COB.
Main Methods:
- Bacteriological isolation and identification of enterococci from patients with COB.
- Assessment of enterococcal pathogenicity markers and antimicrobial susceptibility testing.
- Evaluation of immune responsiveness and autoimmune markers in affected patients.
Main Results:
- Enterococcus faecalis, including subspecies zymogens and liquefaciens, identified as etiological agents of COB.
- Enterococci demonstrated pathogenicity and significant multiple drug resistance.
- COB cases linked to enterococci showed decreased immune responsiveness and developed autoimmune processes.
Conclusions:
- Enterococcus faecalis plays a crucial role in the pathogenesis of chronic obstructive bronchitis, acting as both a primary and secondary infectious agent.
- The multiple drug resistance of these enterococci poses a clinical challenge.
- Enterococcal infections in COB are associated with immune dysregulation, including reduced immunity and autoimmunity.