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Related Experiment Videos

Serum complement and immunoconglutinin in malnutrition

R K Chandra

    Archives of Disease in Childhood
    |March 1, 1975
    PubMed
    Summary

    Malnourished children show reduced serum complement activity and C3 levels, especially with infection. Nutritional rehabilitation and treating infection restored these levels, suggesting a link between malnutrition, complement function, and infection susceptibility.

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    Area of Science:

    • Immunology
    • Nutritional Science
    • Pediatrics

    Background:

    • Malnutrition is linked to immune dysfunction.
    • Complement system plays a crucial role in host defense.
    • Reduced complement activity may increase infection risk in malnourished individuals.

    Purpose of the Study:

    • To investigate serum haemolytic complement activity and C3 levels in malnourished children.
    • To explore the impact of infection on complement levels in malnutrition.
    • To determine the relationship between complement levels and immunoconglutinin titres.

    Main Methods:

    • Measured serum haemolytic complement activity and C3 levels in 35 malnourished children.
    • Utilized electrophoresis to detect altered complement forms.
    • Assessed immunoconglutinin titres and correlated them with C3 levels.

    Main Results:

    • Significantly decreased serum haemolytic complement activity and C3 levels were observed.
    • These changes were more pronounced in malnourished children with concurrent infections.
    • Electrophoretically altered complement forms were detected in 14 children, with an inverse correlation between C3 and immunoconglutinin titres.

    Conclusions:

    • Reduced complement function in malnutrition results from impaired synthesis, in vivo activation, and plasma volume changes.
    • Compromised complement function in malnourished individuals may contribute to increased susceptibility to infections.
    • Nutritional rehabilitation and infection eradication effectively reversed complement abnormalities.

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