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Updated: Jul 8, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Bone mineral density in normal and asthmatic children
K A Kinberg1, R J Hopp, R E Biven
1Department of Pediatrics, Creighton University School of Medicine, Omaha, NE.
The Journal of Allergy and Clinical Immunology
|September 1, 1994
Summary
Children with asthma, even those using inhaled corticosteroids, show no significant difference in bone density compared to healthy children. Bone mass in asthmatic children is primarily influenced by height and age, not asthma severity or treatment.
Area of Science:
- Pediatric Endocrinology
- Respiratory Medicine
- Bone Metabolism
Background:
- Peak bone mass accrual occurs in childhood and adolescence, crucial for lifelong skeletal health.
- Subnormal bone mass increases fracture risk, influenced by genetics, lifestyle, and medical conditions.
- Corticosteroid use and chronic diseases can negatively impact bone density.
Purpose of the Study:
- To evaluate bone density in children with moderate to severe asthma treated with various inhaled and oral corticosteroids.
- To compare bone density in asthmatic children with that of healthy control subjects.
- To identify factors influencing bone density in pediatric asthma patients.
Main Methods:
- Cross-sectional study involving 97 healthy children and 30 children with asthma (aged 5-18).
- Bone density measured using dual-photon or dual-energy absorptiometry.
- Assessment included calcium intake, Tanner stage, and corticosteroid dosage; statistical analyses performed.
Main Results:
- No significant differences in bone density were found between asthmatic children and controls.
- Height and age were the only significant predictors of bone density in asthmatic children.
- Calcium intake, Tanner stage, and corticosteroid dose did not significantly correlate with bone density.
Conclusions:
- Moderate to severe asthma, even with inhaled corticosteroid treatment, does not appear to adversely affect bone mass in children.
- Height and age are key determinants of bone density in this pediatric population.
- A potential for Type II error exists due to the study's sample size.
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