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Prospects for postponing human aging

M R Rose1, T J Nusbaum

  • 1Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine 92717.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|September 1, 1994
PubMed
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Human aging postponement is a growing biomedical research focus, inspired by successes in model organisms like nematodes and fruit flies. Research explores five strategies for extending human lifespan, with varying uncertainty and cost.

Area of Science:

  • Biomedical research
  • Gerontology
  • Longevity science

Background:

  • Human aging postponement has been a long-standing aspiration across cultures.
  • Biomedical research is showing renewed interest in extending lifespan.
  • Successes in postponing aging in model organisms (e.g., Caenorhabditis elegans, Drosophila melanogaster, rodents) have fueled this interest.

Purpose of the Study:

  • To explore the feasibility of achieving human aging postponement.
  • To delineate broad research strategies for extending human lifespan.
  • To compare these strategies based on uncertainty, cost, and delay.

Main Methods:

  • Review of five broad research strategies for aging postponement.
  • Analysis of interventions in model organisms (nematodes, fruit flies, rodents).

Related Experiment Videos

  • Consideration of genetic, cellular, dietary, and selective breeding approaches.

    • Main Results:

    • Aging postponement has been achieved in various laboratory organisms.
    • Five distinct research strategies for human aging postponement are identified.
    • These strategies differ significantly in their associated uncertainty, cost, and projected timelines.

    Conclusions:

    • Extending human lifespan is a plausible goal, supported by animal model research.
    • Multiple research avenues exist for pursuing aging postponement.
    • The choice of strategy will depend on balancing factors like risk, investment, and time.