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Microbial keratitis following penetrating keratoplasty
1Pannu Eye Institute, Lauderdale Lake, Fla.
Ophthalmic Surgery
|June 1, 1994
Summary
Infectious keratitis after corneal transplants is common, with bacteria causing most cases. Prompt treatment is crucial, as only half of grafts remain clear after infection resolution.
Area of Science:
- Ophthalmology
- Microbiology
Background:
- Infectious keratitis following penetrating keratoplasty (PKP) poses a significant threat to graft survival and visual outcomes.
- Understanding the causative pathogens and risk factors is essential for effective management.
Purpose of the Study:
- To evaluate the spectrum of pathogens causing infectious keratitis after PKP.
- To identify factors influencing graft survival in these cases.
Main Methods:
- Retrospective analysis of 36 cases of infectious keratitis in corneal grafts.
- Review of 885 consecutive penetrating keratoplasties.
Main Results:
- Gram-positive cocci and gram-negative rods were equally responsible for 94% of infections (47% each).
- Epithelial defects (64%) and suture-related infections (36%) were primary causes.
- Graft clarity was achieved in only 50% of patients post-resolution.
Conclusions:
- Infectious keratitis significantly impairs graft survival after PKP.
- Early detection and aggressive treatment are vital due to poor visual prognosis.