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Tetracycline resistance determinants in Mycobacterium and Streptomyces species
Y Pang1, B A Brown, V A Steingrube
1Department of Pathobiology, University of Washington, Seattle 98195.
Antimicrobial Agents and Chemotherapy
|June 1, 1994
Abstract:
Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species.