Immunosuppressive therapy of autoimmune diseases

Cyclosporin A, corticosteroids and cyclophosphamide show a remarkable efficacy in a large number of autoimmune diseases. However, their effect is dependent on continuous drug administration with potential risks of drug toxicity and over immunosuppression. Results recently obtained in animal models, particularly with anti-CD3 and anti-CD4 monoclonal antibodies, indicate that reestablishment of tolerance to self antigens is a feasible goal.