Related Experiment Videos
Naturally occurring atriocaval mesotheliomas in rats
M Chandra1, H Davis, W W Carlton
1Experimental Pathology Department, American Cyanamid Company, Pearl River, New York.
Journal of Comparative Pathology
|November 1, 1993
Summary
Two control Sprague-Dawley rats developed atriocaval mesotheliomas. These rare neoplasms, located at the interventricular septum base, exhibited glandular structures and epithelial cells positive for vimentin and cytokeratin.
Area of Science:
- Veterinary Pathology
- Oncology
- Toxicology
Background:
- Atriocaval mesotheliomas are rare neoplasms.
- Spontaneous occurrence in Sprague-Dawley rats is infrequently reported.
Purpose of the Study:
- To document the occurrence and characteristics of atriocaval mesotheliomas in control Sprague-Dawley rats.
- To provide detailed histopathological and immunohistochemical data for these rare tumors.
Main Methods:
- Histopathological examination of neoplasms from control rats.
- Immunohistochemical staining for vimentin and cytokeratin.
- Electron microscopy to analyze cellular ultrastructure.
Main Results:
- Two cases of atriocaval mesothelioma were identified in 2889 control rats.
- Neoplasms were located at the interventricular septum base.
- Histologically, tumors showed glandular structures lined by atypical epithelium; immunohistochemistry confirmed vimentin and cytokeratin expression. Ultrastructural analysis revealed features consistent with epithelial differentiation.
Conclusions:
- Atriocaval mesotheliomas can occur spontaneously in Sprague-Dawley rats.
- These findings contribute to the understanding of rare tumor incidence in control animal populations.
- Detailed characterization aids in distinguishing these tumors from other cardiac or vascular lesions.