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Slow weight gain is associated with increased periodic breathing in healthy infants
L L Riordan1, D H Kelly, D C Shannon
1Pediatric Pulmonary Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Insights
Slow weight gain in infants is linked to more frequent periodic breathing. This study tracked breathing patterns and weight in newborns, finding a clear connection between slower growth and increased breathing irregularities.
Area of Science:
- Neonatal physiology
- Infant respiratory health
Background:
- Periodic breathing is common in healthy infants.
- Factors influencing periodic breathing require further investigation.
Purpose of the Study:
- To examine the relationship between infant weight gain and periodic breathing.
- To determine if weight gain influences the prevalence of periodic breathing in the first two months of life.
Main Methods:
- Prospective study of 99 full-term infants using nocturnal pneumography.
- Respiration and heart rate monitored during the first and second months of life.
- Analysis of percent periodic breathing (%PB) and correlation with weight gain.
Main Results:
- Median %PB decreased from 0.9 to 0.3 between the first and second months.
- %PB was inversely correlated with weight gain.
- Greater weight gain was associated with a significant reduction in %PB.
Conclusions:
- Slow weight gain in early infancy is associated with increased periodic breathing.
- Weight gain appears to be a significant factor in resolving periodic breathing patterns.
- Findings suggest monitoring infant weight gain may be relevant for assessing respiratory patterns.
Abstract:
To investigate the hypothesis that weight gain can influence periodic breathing in healthy infants, we prospectively studied, by nocturnal pneumogram technique, respiration and heart rate in 99 full-term infants during the first month of life. Eighty-eight infants had a repeat study at about 2 months of age. Pneumograms were analyzed visually for percent periodic breathing (%PB), and by computer for mean respiratory rate and mean heart rate. We found a median %PB of 0.9 initially and of 0.3 at about 2 months of age. The 95th percentile was 13.5 at 2 weeks and 7.3 at 2 months, higher than previously reported. Between the two ages tested, %PB was inversely correlated with weight gain (P < 0.001, < 0.03, respectively). Infants with greater weight gain had a greater fall in %PB (P < 0.03). We conclude that in the first 2 months of life, slow weight gain is associated with increased periodic breathing.
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