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Radiosurgery of cavernous sinus tumors
A A De Salles1, C L Bajada, S Goetsch
1Division of Neurosurgery, School of Medicine, University of California, Los Angeles.
Acta Neurochirurgica. Supplementum
|January 1, 1993
Summary
Stereotactic radiosurgery effectively treated cavernous sinus tumors, including meningiomas and pituitary tumors. This advanced radiation technique shows promise in managing these complex brain lesions.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Cavernous sinus tumors present unique treatment challenges due to their proximity to critical neurovascular structures.
- Traditional treatment modalities may have limitations in achieving local tumor control while preserving function.
Purpose of the Study:
- To evaluate the feasibility and outcomes of using stereotactic radiosurgery for treating various tumors within the cavernous sinus.
- To assess the efficacy of linac-based radiosurgery in managing meningiomas, pituitary tumors, and metastatic lesions in this region.
Main Methods:
- Stereotactic radiosurgery utilizing a linear accelerator was performed on 18 patients with cavernous sinus tumors (10 meningiomas, 5 pituitary, 3 metastatic).
- Treatment planning involved CT and MRI to delineate tumor margins and critical structures, with doses ranging from 1400 to 2500 cGy prescribed to the tumor margin.
- Follow-up ranged from 3 to 18 months, assessing both symptomatic and radiographic responses.
Main Results:
- Symptomatic improvement or stabilization was observed in 15 out of 18 patients.
- Radiographic evidence of tumor response or stability was seen in 11 out of 14 evaluable patients.
- No significant complications were detailed, suggesting a favorable safety profile.
Conclusions:
- Linear accelerator-based stereotactic radiosurgery is a feasible and effective treatment option for cavernous sinus tumors.
- This radiosurgical approach offers a valuable non-invasive therapeutic strategy, potentially complementing surgical resection for these challenging tumors.