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Fluconazole-resistant Candida albicans

D J Boken1, S Swindells, M G Rinaldi

  • 1Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5400.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 1, 1993
PubMed
Summary
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Fluconazole-resistant Candida albicans is an emerging concern in patients with human immunodeficiency virus (HIV) infection. This study analyzes factors contributing to antifungal resistance and treatment failures in HIV-positive individuals.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Mucocutaneous candidiasis is a frequent opportunistic infection in individuals with human immunodeficiency virus (HIV).
  • Emerging reports indicate an increase in fluconazole-resistant strains of Candida albicans.
  • Limited data exists on the specific circumstances promoting antifungal resistance in HIV-infected populations.

Observation:

  • This study retrospectively reviewed cases of fluconazole-resistant candidiasis in patients with HIV infection.
  • Candida albicans strains isolated during relapse were tested for antifungal susceptibility.
  • The study examined potential reasons for antifungal therapy failure and correlated in vivo and in vitro findings.

Findings:

  • Fluconazole resistance in Candida albicans is an increasing challenge in HIV-infected patients.

Related Experiment Videos

  • Analysis of relapse strains provides insights into the mechanisms of resistance.
  • Correlation between in vivo treatment outcomes and in vitro susceptibility data was investigated.

    • Implications:

    • Resistant candidiasis poses a significant and growing threat to immunocompromised individuals, particularly those with HIV.
    • Further research is crucial to understand and combat the rise of antifungal resistance.
    • This study highlights the need for vigilant monitoring and tailored treatment strategies for candidiasis in HIV patients.