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Related Experiment Videos

Interictal autonomic nervous system function in patients with epilepsy

O Devinsky1, K Perrine, W H Theodore

  • 1Clinical Epilepsy Section, NINDS, NIH, Bethesda, Maryland.

Epilepsia
|January 1, 1994
PubMed
Summary

Patients with epilepsy show greater blood pressure and heart rate variability. Carbamazepine (CBZ) therapy may influence autonomic responses, suggesting a link between epilepsy, medication, and autonomic function.

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Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Clinical Pharmacology

Background:

  • Epilepsy is a neurological disorder affecting millions worldwide.
  • Autonomic nervous system (ANS) dysfunction is increasingly recognized in epilepsy.
  • Carbamazepine (CBZ) is a common antiepileptic drug with potential autonomic effects.

Purpose of the Study:

  • To investigate autonomic nervous system function in patients with partial seizures on carbamazepine monotherapy.
  • To compare autonomic responses between epilepsy patients and healthy controls.
  • To assess the influence of carbamazepine therapy on autonomic parameters.

Main Methods:

  • Studied 24 epilepsy patients on carbamazepine (CBZ) and 40 healthy controls.
  • Assessed autonomic function via heart rate (HR) and blood pressure (BP) during orthostasis, cold pressor test (CPT), Valsalva maneuver, and cold face test with apnea (CFTA).

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  • 17 controls were tested with and without CBZ to isolate drug effects.

    • Main Results:

    • Epilepsy patients exhibited significantly higher BP and HR variability and reactivity during orthostasis and CPT compared to controls.
    • Epilepsy patients showed greater initial BP increases and subsequent decreases during CPT.
    • Carbamazepine therapy in controls was associated with higher HR during orthostasis and CFTA.
    • CBZ levels correlated with baseline and orthostatic BP and HR during deep breathing.

    Conclusions:

    • Patients with epilepsy demonstrate altered autonomic nervous system responses, characterized by increased BP and HR variability and reactivity.
    • Carbamazepine therapy may contribute to these autonomic variations.
    • Findings suggest a complex interplay between epilepsy, antiepileptic drugs like CBZ, and autonomic regulation.