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Mercury excretion and intravenous ascorbic acid

M J Dirks1, D R Davis, E Cheraskin

  • 1Center for Improvement of Human Functioning International, Inc., Wichita, Kansas.

Archives of Environmental Health
|January 1, 1994
PubMed
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Intravenous ascorbic acid did not significantly increase mercury or lead excretion in adults with low mercury levels. This study suggests potential benefits of ascorbic acid for mercury reactions are not linked to short-term heavy metal excretion.

Area of Science:

  • Environmental Toxicology
  • Nutritional Biochemistry
  • Clinical Pharmacology

Background:

  • Mercury exposure from dental amalgam, food, and other sources is a public health concern.
  • Ascorbic acid (vitamin C) has been anecdotally suggested to aid in mercury detoxification.
  • Understanding the physiological impact of intravenous ascorbic acid on heavy metal excretion is crucial.

Purpose of the Study:

  • To investigate whether intravenous ascorbic acid administration enhances urinary mercury and lead excretion.
  • To test the hypothesis that ascorbic acid facilitates the removal of mercury in individuals with low to moderate mercury levels.

Main Methods:

  • A randomized controlled trial involving 28 adult volunteers with the highest mercury excretion rates.
  • Administration of intravenous infusions: 500 ml lactated Ringer's solution with and without 750 mg/kg body weight ascorbic acid (up to 60 g).

Related Experiment Videos

  • Measurement of urinary mercury and lead excretion over 24 hours post-infusion.

    • Main Results:

    • Average mercury excretion was 4.0 ± 0.5 micrograms/24h after ascorbic acid infusion, compared to 3.7 ± 0.5 micrograms/24h after Ringer's solution alone.
    • The difference in mercury excretion between the two conditions was not statistically significant.
    • Lead excretion levels also remained unaffected by ascorbic acid administration.

    Conclusions:

    • Intravenous ascorbic acid does not significantly increase short-term urinary excretion of mercury or lead in subjects with low mercury burdens.
    • Observed benefits of ascorbic acid in individuals with suspected mercury reactions may not be mediated by enhanced heavy metal excretion.
    • Further research is needed to elucidate the mechanisms behind any potential therapeutic effects of ascorbic acid in mercury-related conditions.