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Sodium fluoride therapy

J R Causse¹, J B Causse, J Uriel

¹Clinique d'Otologie Jean Causse Traverse de Béziers, Colombiers, France.

The American Journal of Otology

|September 1, 1993

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Sodium fluoride can treat otospongiosis-otosclerosis by inhibiting bone resorption and rebuilding bone. This medical treatment helps prevent or arrest hearing loss associated with the condition.

Area of Science:

Otolaryngology
Pharmacology
Bone Biology

Background:

Otospongiosis-otosclerosis is a condition characterized by abnormal bone remodeling in the labyrinth.
This bony change can lead to progressive hearing loss.

Purpose of the Study:

To evaluate the efficacy of sodium fluoride as a medical treatment for otospongiosis-otosclerosis.
To understand the mechanism by which sodium fluoride influences bony changes and hearing loss.

Main Methods:

The study focuses on the pharmacological action of sodium fluoride.
It examines its effect as an enzyme inhibitor on osteoclastic bone resorption.

Main Results:

Sodium fluoride influences labyrinthine bony changes in otospongiosis-otosclerosis.

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It effectively arrests or prevents the onset of hearing loss.

Dosages exceeding 60 mg daily may promote the rebuilding of pseudohaversian bone.

Conclusions:

Sodium fluoride demonstrates therapeutic potential for otospongiosis-otosclerosis.
Its mechanism involves inhibiting bone resorption and potentially rebuilding bone structure.
This offers a strategy to manage or prevent hearing loss in affected individuals.