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Host and environmental effects on plasma apolipoprotein B
G P Jarvik1, E Wijsman, R E Little
1Department of Medicine, University of Washington, Seattle 98195.
International Journal of Clinical & Laboratory Research
|January 1, 1993
Summary
Apolipoprotein B (apo B) levels vary with age and gender, influenced by height, weight, smoking, and diabetes. These factors explain 21% of apo B variations in middle-aged adults.
Area of Science:
- Cardiovascular Health
- Lipid Metabolism
- Biomarkers
Background:
- Apolipoprotein B (apo B) is a key component of atherogenic lipoproteins.
- Understanding apo B variations is crucial for cardiovascular risk assessment.
- Limited data exists on apo B levels in diverse middle-aged populations.
Purpose of the Study:
- To describe apolipoprotein B (apo B) levels in an unselected sample of middle-aged Caucasian individuals.
- To identify demographic and lifestyle factors associated with apo B variations.
Main Methods:
- Analysis of apo B levels in 487 middle-aged Caucasian participants.
- Statistical adjustment for age, gender, height, weight, smoking, and diabetes status.
Main Results:
- Male apo B levels peaked in the 7th decade, while female levels increased linearly with age.
- Height, weight, smoking, and non-insulin-dependent diabetes mellitus significantly impacted apo B levels.
- These factors collectively explained 21% of the total variation in apo B levels.
Conclusions:
- Age, gender, anthropometric measures, smoking, and diabetes are significant determinants of apo B levels.
- These findings contribute to understanding apo B variability in cardiovascular health.