Improved detection and derivatization in capillary electrophoresis

Capillary electrophoresis is well known for its low mass detectabilities, but suffers from poor concentration detection limits. This review will discuss improvements in concentration detectability with an emphasis on derivatization methods. Sample concentration techniques and improved detector designs will also be discussed. Pre- and post-capillary derivatization methods for biofluid analytes such as amino acids, peptides, proteins, oligonucleotides, and oligosaccharides will be examined in detail.