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Synovial sarcoma of the extremities
International Orthopaedics
|November 1, 1993
Summary
This study found that combining surgery with CYVADIC chemotherapy and radiotherapy is an effective treatment for stage II synovial sarcoma of the extremities, improving survival rates.
Area of Science:
- Orthopedics
- Medical Oncology
Background:
- Synovial sarcoma is a rare soft tissue sarcoma.
- Enneking's stage II classification indicates a malignant tumor with extracompartmental extension.
Purpose of the Study:
- To evaluate the effectiveness of combined modality treatment for stage II extremity synovial sarcoma.
- To determine survival and disease-free survival rates.
Main Methods:
- Retrospective analysis of 18 patients with stage II synovial sarcoma treated between May 1985 and March 1990.
- Treatment included surgery, CYVADIC chemotherapy, and optionally radiotherapy.
- Average follow-up was 34.7 months.
Main Results:
- Estimated 5-year survival rate was 78.4%.
- Estimated 5-year continuously disease-free survival rate was 44.4%.
- Outcomes improved with adequate surgery or chemotherapy for recurrence or metastases.
Conclusions:
- The combination of surgery and CYVADIC chemotherapy with or without radiotherapy is an effective treatment for stage II synovial sarcoma of the extremities.
- Adjuvant therapies can improve outcomes in cases of recurrence or metastasis.