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Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat
A Lücke1, A Lehmenkühler, U Altrup
1Institut für Physiologie der Universität Münster, FRG.
Brain Research
|December 24, 1993
Abstract:
The diffusion of valproate (VPA) and trans-2-en-valproate were studied in agar gel and in the cerebral cortex of the rat using pressure microejection and VPA-selective microelectrodes. From the agar measurements a free diffusion coefficient for VPA of 6.52 x 10(-6) cm2.s-1 and for trans-2-en-VPA of 5.25 x 10(-6) cm2.s-1 for 37 degrees C was determined. The tortuosity value in the cortex was 1.92 for VPA and 1.67 for trans-2-en-VPA. The tortuosity values suggest that VPA and trans-2-en-VPA diffuse mainly in the extracellular space of the brain.