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Benign transient hyperphosphatasemia

B Z Garty1, M Nitzan

  • 1Department of Pediatrics, Children's Medical Center of Israel, Petah Tikva.

Israel Journal of Medical Sciences
|January 1, 1994
PubMed
Summary
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Benign transient hyperphosphatasemia (BTHP) is a temporary condition causing high alkaline phosphatase (AP) levels in children, often linked to infections. This self-resolving disorder requires no further investigation, preventing unnecessary medical tests.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry

Background:

  • Benign transient hyperphosphatasemia (BTHP) is a rare, self-limiting condition characterized by markedly elevated serum alkaline phosphatase (AP) levels.
  • It is typically observed in infants and young children, often incidentally discovered during mild infections or routine health check-ups.

Purpose of the Study:

  • To describe the clinical features and diagnostic criteria of BTHP in a pediatric cohort.
  • To emphasize the importance of recognizing BTHP to avoid unnecessary diagnostic workups for liver or bone disease.

Main Methods:

  • Retrospective case series analysis of nine children diagnosed with BTHP over a two-year period.
  • Review of clinical presentations, laboratory findings (specifically serum alkaline phosphatase levels), and follow-up data.

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Main Results:

  • Nine children diagnosed with BTHP, presenting with 3-50 fold elevation in serum AP levels.
  • Elevated AP levels were associated with mild infections (respiratory or gastrointestinal) and normalized within 12 weeks.
  • No evidence of underlying bone or liver pathology was found in any patient.

Conclusions:

  • BTHP is a benign, transient condition that can be diagnosed based on characteristic laboratory findings and clinical presentation.
  • Prompt recognition of BTHP can prevent extensive and unnecessary investigations for more serious conditions.
  • Awareness among pediatricians is crucial for accurate diagnosis and appropriate patient management.