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Physicochemical characterization of acetaminophen-ethylcellulose solid dispersion

E S Ghaly1, J I Hernández, A Malavé

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.

Puerto Rico Health Sciences Journal
|December 1, 1993
PubMed
Summary

Ethylcellulose effectively prepared sustained-release acetaminophen using solid dispersion. This method offers a promising approach for controlled drug delivery, enhancing acetaminophen

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Acetaminophen is a widely used analgesic and antipyretic.
  • Developing sustained-release formulations can improve therapeutic efficacy and patient compliance.

Purpose of the Study:

  • To evaluate ethylcellulose as a carrier for sustained-release acetaminophen.
  • To prepare acetaminophen solid dispersions using ethylcellulose.
  • To investigate potential interactions between acetaminophen and ethylcellulose.

Main Methods:

  • Solid dispersion technique was employed to prepare acetaminophen-ethylcellulose systems.
  • Physical mixtures of acetaminophen and ethylcellulose were also prepared for comparison.
  • Differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were utilized for characterization.

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Main Results:

  • Ethylcellulose was successfully used as a carrier for acetaminophen solid dispersions.
  • Characterization confirmed the physical properties of the prepared systems.
  • Analysis indicated no significant adverse interactions between acetaminophen and ethylcellulose.

Conclusions:

  • Ethylcellulose is a suitable carrier for preparing sustained-release acetaminophen formulations via solid dispersion.
  • The solid dispersion technique is effective for controlled acetaminophen release.
  • The compatibility of acetaminophen with ethylcellulose supports its use in drug delivery systems.