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Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy
T H Zastawny1, W Olejniczak, R Oliński
1Department of Clinical Biochemistry, Medical School, Bydgoszcz, Poland.
Acta Biochimica Polonica
|January 1, 1993
Abstract:
Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.