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Assessment of currently available low-density lipoprotein apheresis systems
Y Matsuda1, P S Malchesky, Y Nosé
1Department of Surgery, Baylor College of Medicine, Houston, TX 77030.
Artificial Organs
|January 1, 1994
Summary
Low-density lipoprotein (LDL) apheresis technologies have been available for 10 years. A review of six systems suggests a need to reconsider the specificity of LDL removal in atherosclerosis treatment.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
Background:
- Low-density lipoprotein (LDL) apheresis technologies have been clinically available for a decade.
- These methods are established as technically feasible, medically safe, and economically viable for long-term atherosclerosis management.
Purpose of the Study:
- To critically review the current strategy of LDL apheresis in light of evolving understanding of atherosclerosis pathogenesis.
- To evaluate and compare six available LDL apheresis systems.
Main Methods:
- Review and scoring of six LDL apheresis systems: plasma exchange, double filtration plasmapheresis, thermofiltration, Kaneka system, LDL immunoadsorption, and HELP system.
- Assessment criteria included effectiveness, simplicity, safety, and cost-performance.
Main Results:
- The study provides a comprehensive review of established LDL apheresis technologies.
- Each system is scored and assessed based on multiple performance metrics.
Conclusions:
- While LDL apheresis is effective, the current focus on highly specific LDL removal may be too narrow given the complexity of atherosclerosis.
- A broader perspective considering multiple macromolecules in lipid-related diseases is recommended for future apheresis strategies.