Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New platinum antitumor complexes

L R Kelland1

  • 1Section of Drug Development, Institute of Cancer Research, Belmont, Sutton, Surrey, UK.

Critical Reviews in Oncology/Hematology
|December 1, 1993
PubMed
Summary

Platinum-based chemotherapy drugs like cisplatin and carboplatin are effective cancer treatments. Future research focuses on overcoming tumor resistance to these drugs and developing new platinum-based compounds for improved clinical utility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bcl-2 family immunohistochemistry.

Methods in molecular medicine·2011
Same author

Guidelines for the welfare and use of animals in cancer research.

British journal of cancer·2010
Same author

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.

British journal of cancer·2005
Same author

Small molecule anticancer drugs.

IDrugs : the investigational drugs journal·2005
Same author

Antitumor activity of imidazothioxanthones in murine and human tumor models in vitro and in vivo.

Anticancer research·2004
Same author

Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development.

European journal of cancer (Oxford, England : 1990)·2004

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Platinum-based drugs, including cisplatin and carboplatin, have significantly benefited cancer patients for two decades.
  • Despite their success, there is a need for improved metal coordination complexes and strategies to overcome tumor resistance.

Purpose of the Study:

  • To explore novel platinum-based complexes and alternative metal compounds for enhanced cancer therapy.
  • To focus on understanding and circumventing tumor resistance mechanisms to existing platinum drugs.

Main Methods:

  • Reviewing current understanding of cisplatin resistance mechanisms and DNA interactions.
  • Investigating novel platinum-based drug development targeting resistance pathways.
  • Considering non-platinum drugs that modulate resistance pathways.

Main Results:

  • 1,2-diaminocyclohexane platinum complexes show promise in preclinical models for overcoming cisplatin resistance.
  • Early clinical trials are underway for these novel agents, but their efficacy in refractory disease and neurotoxicity require further evaluation.

Conclusions:

  • Increased understanding of cisplatin resistance mechanisms will guide the development of next-generation platinum drugs.
  • Strategies include designing drugs to overcome reduced drug accumulation or enhanced DNA adduct removal.
  • Combination therapies with non-platinum drugs modulating resistance pathways offer future clinical benefits.

Related Experiment Videos