[Influence of burn shock on the prognosis of burn wound sepsis in mice]

The influence of burn shock on the prognosis of burn wound sepsis was investigated in mice. Mice with full-thickness burn of 13% TBSA was injected subcutaneously under the burned area immediately after burning with 0.2ml P. aeruginosa (1 x 10(3)CFU/ml) or 0.2 ml K. pneumoniae (5 x 10(3)CFU/ml). The survival rate in P. aeruginosa burn wound sepsis was 49% in resuscitation group (n = 53) on 7 postburn day and 17% in non-resuscitation group (n = 24) (P < 0.01). The mean survival time in dead mice of resuscitation group (n = 27) was 4.2 +/- 1.7 days and 2.5 +/- 0.6 days in that of non-resuscitation group (n = 20) (p < 0.01). The survival rate in K. pneumoniae burn wound sepsis was 69% in resuscitation group (n = 26) on 7 postburn day and 15% in non-resuscitation group (n = 13) (P < 0.01). The mean survival time in dead mice of resuscitation group (n = 8) was 5 +/- 1.35 days and 2.1 +/- 0.3 days in that of non-resuscitation group (n = 11) (p < 0.01). These results indicated that burn shock might increase the mortality of burn wound sepsis and resuscitation could improve the prognosis of burn wound sepsis.