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[An analysis on the reported values of trace elements in human serum]
1Institute of Geochemistry Chinese Academy of Sciences, Guiyang.
Summary
Trace element levels in human serum have significantly decreased over 30 years due to improved analytical methods and contamination control. This study provides updated normal values for essential elements like copper and zinc.
Area of Science:
- Analytical Chemistry
- Human Physiology
- Environmental Science
Context:
- Over the past 30 years, advancements in analytical techniques and contamination control have influenced reported trace element concentrations in human serum.
- Previous studies often presented trace element data using log-normal distributions.
Purpose:
- To analyze trends in human serum trace element data over three decades.
- To establish reliable normal values for key trace elements based on current analytical standards.
Summary:
- Statistical analysis reveals a significant decrease in reported human serum trace element values, approaching true physiological levels.
- Data distributions are shifting from log-normal to normal, with reduced variability.
- Presents updated normal, estimated normal, and literature values for 13 trace elements (Cu, Zn, Se, Co, Mo, Mn, Cr, Ni, As, Rb, Br, Cs, Al).
Impact:
- Provides a crucial update for clinical diagnostics and nutritional assessments.
- Establishes a benchmark for interpreting human serum trace element concentrations.
- Highlights the importance of analytical methodology in biological trace element research.