Related Experiment Video
Updated: Aug 2, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
[Estrogens, progestins and cancer of the endometrium]
1Service de gynécologie obstétrique, hôpital Arnaud-de-Villeneuve, Montpellier.
Abstract:
The presence of estrogens alone increases the risk of cancer of the endometrium. The risk increases with dosage and length of administration. Estrogens have a promoting rather than an initiating role since the risk progressively disappears after stopping treatment. Hormone-induced cancers have a better prognosis than spontaneous cancers. The association of progesterone or a progestogen obviates this risk. Prescription of oestrogens after treatment of cancer of the endometrium is non longer strictly contraindicated. Each case should be considered independently.
Related Concept Videos
Mitogens and the Cell Cycle
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Ovarian Cycle
The Menstrual Cycle
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Proliferative Phase
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

