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[Penicillamine-induced elastosis perforans serpiginosa]
1Klinik für Dermatologie und Venerologie, Medizinischen Universität, Lübeck.
Summary
Elastosis perforans serpiginosa is a rare skin condition with various causes. This case study details a patient whose condition developed due to prolonged use of the chelating drug D-penicillamine.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Elastosis perforans serpiginosa (EPS) is a rare connective tissue disorder.
- Its etiology is often idiopathic or associated with various systemic conditions.
- Drug-induced cases are infrequently reported.
Observation:
- A 33-year-old male presented with clinical and histological findings consistent with EPS.
- The patient had a history of long-term treatment with D-penicillamine for an unrelated condition.
Findings:
- The clinical presentation and biopsy results confirmed Elastosis perforans serpiginosa.
- Causal link established between D-penicillamine therapy and the development of EPS.
- Histopathological examination revealed characteristic changes in the dermal elastic tissue.
Implications:
- Highlights D-penicillamine as a potential iatrogenic cause of Elastosis perforans serpiginosa.
- Suggests vigilance for EPS in patients on long-term D-penicillamine treatment.
- Contributes to understanding the variable etiology of this rare dermatosis.