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Ageing and acetylcholine release by tityustoxin from brain cortical slices
I B Queiroz1, R M Turchetti-Maia, T Moraes-Santos
1Departamento de Farmacologia, Faculdade, de Farmácia, Instituto de Ciências Biológicas-UFMG, Belo Horizonte, Brazil.
Abstract:
The ability of tityustoxin to trigger acetylcholine release was studied in cerebral cortical slices from 2, 12 and 23-month-old rats. The effect of tityustoxin to induce the release of acetylcholine was reduced by 60% in senescent animals. This result suggests that ageing reduces the sensitivity of cerebral cortical nerve terminals to tityustoxin.