Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of cancer cachexia

U Keller1

  • 1Department of Internal Medicine, University Hospital, Basel, Switzerland.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|November 1, 1993
PubMed
Summary

Cancer cachexia involves increased energy expenditure and muscle loss, driven by tumor mediators like cytokines. Inhibiting these cytokines partially prevents cachexia in animal models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tightly locked optical frequency comb from a semiconductor disk laser.

Optics express·2019
Same author

Programmable pulse shaping for time-gated amplifiers.

Optics express·2019
Same author

Sub-150-fs pulses from an optically pumped broadband modelocked integrated external-cavity surface emitting laser.

Optics letters·2019
Same author

High-power OPCPA generating 1.7 cycle pulses at 2.5 µm.

Optics express·2018
Same author

Orientation-dependent stereo Wigner time delay and electron localization in a small molecule.

Science (New York, N.Y.)·2018
Same author

Gas-lens effect in kW-class thin-disk lasers.

Optics express·2018

Area of Science:

  • Oncology
  • Metabolic Medicine
  • Immunology

Background:

  • Cancer cachexia is a complex syndrome characterized by increased energy expenditure, anorexia, and significant muscle protein loss.
  • It differs from simple starvation, showing metabolic similarities to sepsis and polytrauma.
  • The condition is largely mediated by substances released by the tumor or the host, including cytokines and catabolic hormones.

Purpose of the Study:

  • To investigate the role of cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, and interferon gamma (IFN-γ), in the development of cancer cachexia.
  • To explore the potential of inhibiting cytokine activity as a therapeutic strategy for cancer cachexia.

Main Methods:

  • Review of existing literature on cancer cachexia pathophysiology.
  • Experimental studies involving cancer-bearing animals treated with specific cytokine inhibitors (antibodies).
  • Analysis of metabolic changes including energy expenditure, glucose metabolism, and protein redistribution.

Main Results:

  • Cytokines like TNF-α, IL-1, IL-6, and IFN-γ are implicated in cancer cachexia, with evidence of increased production in certain cancers.
  • Inhibition of cytokine activity using antibodies partially prevented cachexia in experimental animals.
  • A positive feedback loop between macrophage-derived IL-1 and tumor-derived IL-6 was observed in experimental models.

Conclusions:

  • Cytokines play a significant role in mediating cancer cachexia and may also promote tumor growth.
  • Targeting cytokine activity presents a potential therapeutic avenue for managing cancer cachexia.
  • Further research is needed to clarify the specific contribution of each cytokine and optimize therapeutic interventions.

Related Experiment Videos